Pipeline

Our programs are built on a first-in-class DES1 inhibition platform with broad applicability across CKM diseases. By targeting ceramide overproduction upstream, we aim to impact multiple renal, cardiac, and metabolic indications.

Lead asset: CNT2130 currently in clinical trials

A once-daily, oral DES1 inhibitor with demonstrated therapeutic activity across kidney, cardiac, hepatic, and metabolic endpoints. Supported by extensive human lipidomic, genetic, and pharmacological validation and IND-enabling safety data, CNT2130 has a clear path to clinical proof-of-concept in DKD and beyond.

Program

Modality

Initial
Indication

Phase

CNT2130

Small molecule
DES1 inhibitor

Diabetic Kidney
Disease (DKD)

Discovery

Preclinical

Phase 1

Phase 2

Phase 3

CNT2198

Small molecule
DES1 inhibitor

Acute Kidney
Injury/rare diseases

Discovery

Preclinical

Phase 1

Phase 2

Phase 3

2nd-Gen DES1
Inhibitors

Small molecules

Cardio-Kidney-
Metabolic diseases

Discovery

Preclinical

Phase 1

Phase 2

Phase 3